Context:
The primary objective of this project is to develop a novel lead compound, particularly an antibiotic, adept at inhibiting the FabI enzyme and combatting critical gram-negative pathogens.
Relevance:
GS III: Science and Technology
Dimensions of the Article:
- Gram-negative bacteria
- Technology Development Board (TDB)
Gram-negative bacteria:
Cell Wall Structure:
- They possess a thinner peptidoglycan cell wall compared to Gram-positive bacteria.
- Additionally, they have an outer membrane containing lipopolysaccharides, making them diderms.
Antibiotic Resistance:
- Gram-negative bacteria can evolve resistance to antibiotics more effectively.
- They can transfer genetic materials to other bacteria, facilitating the spread of antibiotic resistance.
Infections Caused:
- Common infections associated with Gram-negative bacteria include pneumonia, bloodstream infections, wound or surgical site infections, and meningitis, especially in healthcare settings.
Antibiotic Resistance:
- These bacteria often display resistance to multiple drugs and are increasingly resistant to many available antibiotics.
Examples:
- Notable Gram-negative bacteria include species from enterobacter, salmonella, and pseudomonas genera.
Technology Development Board (TDB):
Establishment:
- TDB is a statutory body established under the Technology Development Board Act of 1995.
Objective:
- The primary goal of TDB is to foster the development and commercialization of indigenous technology and to adapt imported technology for broader application within India.
Composition:
- The board comprises 11 members who oversee its operations and decisions.
Financial Support:
- TDB offers equity capital or loans to industrial enterprises and provides financial aid to research and development institutions.
Funding:
- The Board receives grants from the Government of India. These grants are sourced from cess collections from industrial entities as per the provisions of the Research and Development Cess Act of 1986, amended in 1995.
